下个月或达感染高峰!这两种药完全无效
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<span style="font-size: 16px;"><strong style="outline: 0px;visibility: visible;"><span style="outline: 0px;visibility: visible;">北京市疾控中心发布提醒:青霉素和头孢对肺炎支原体完全无效</span></strong><span style="outline: 0px;visibility: visible;">,市民如果出现发热伴有剧烈咳嗽,应及时就诊,尽快查明病因、规范治疗,切忌自行盲目用药。</span></span>
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<span style="font-size: 16px;"><strong style="outline: 0px;visibility: visible;"><span style="outline: 0px;background-color: #007aaa;color: #ffffff;visibility: visible;">11月为北京支原体肺炎高峰期<br style="outline: 0px;visibility: visible;"/></span></strong><strong style="outline: 0px;font-size: var(--articleFontsize);letter-spacing: 0.034em;visibility: visible;"><span style="outline: 0px;background-color: #007aaa;color: #ffffff;visibility: visible;">患者切忌盲目用药</span></strong></span>
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<span style="outline: 0px;visibility: visible;font-size: 16px;" >肺炎支原体分为Ⅰ型和Ⅱ型共两种亚型,目前北京市主要流行亚型为Ⅰ型。人群对肺炎支原体普遍易感,但好发于5岁以上儿童和青少年。肺炎支原体感染潜伏期1~3周,潜伏期内至症状缓解数周均有传染性。肺炎支原体感染症状以发热、咳嗽等为主要症状,一般咳嗽比较剧烈,而且在发热退后咳嗽还可能继续1~2周。</span>
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<span style="outline: 0px;visibility: visible;font-size: 16px;">肺炎支原体感染可引起上呼吸道感染,也可引起肺炎等下呼吸道感染,还可引起肺外并发症,如自身免疫性溶血性贫血等。</span>
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<span style="outline: 0px;font-size: 16px;">由于肺炎支原体没有细胞壁,大家所熟悉的青霉素和头孢,这类抗生素都是以细胞壁作为靶点,因此对肺炎支原体完全无效。大环内酯类抗菌药物,如罗红霉素、阿奇霉素,目前为肺炎支原体感染的首选治疗药物。因此,市民如果出现发热伴有剧烈咳嗽,应及时就诊,尽快查明病因,规范治疗,切忌自行盲目用药。</span>
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<span style="outline: 0px;font-size: 16px;">目前还没有预防肺炎支原体感染的疫苗。预防肺炎支原体感染,最重要的是养成良好的个人卫生习惯。</span>
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<span style="outline: 0px;font-size: 16px;">1.尽量避免到人群密集和通风不良的公共场所,必要时戴好口罩防护自己。</span>
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<span style="outline: 0px;font-size: 16px;">2.咳嗽、打喷嚏时使用纸巾捂住口鼻,或用手肘或上袖等遮挡,将用过的纸巾丢入带盖垃圾桶中。</span>
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<span style="outline: 0px;font-size: 16px;">3.注意手卫生,使用肥皂、洗手液在流动水下清洁洗手。如果没有流动水,可用含酒精的免洗洗手液等擦拭消毒双手。</span>
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<span style="outline: 0px;font-size: 16px;">4.流行高发季节,注意室内通风,每次通风不少于30分钟,以保持空气新鲜。</span>
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<span style="outline: 0px;font-size: 16px;">5.养成健康生活习惯,适量运动,增加身体抵抗力,注意保暖避免受凉。</span>
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<span style="outline: 0px;font-size: 16px;">6.学校、幼儿园等重点场所要注意通风消毒,做好日常的清洁工作,加强健康监测,避免出现聚集性感染。</span>
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<span style="font-size: 16px;"><strong style="outline: 0px;"><span style="outline: 0px;background-color: #007aaa;color: #ffffff;">权威解答:治疗支原体肺炎,<br style="outline: 0px;"/></span></strong><strong style="outline: 0px;font-size: var(--articleFontsize);letter-spacing: 0.034em;"><span style="outline: 0px;background-color: #007aaa;color: #ffffff;">首选药物是什么?需要住院吗?</span></strong></span>
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<span style="outline: 0px;font-size: 16px;">目前已知,青霉素和头孢对肺炎支原体完全无效,那治疗肺炎支原体感染,首选药物是什么?是否会产生耐药性?什么情况下需要住院治疗?北京市卫生健康委进行了解答。</span>
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<span style="font-size: 16px;"><strong style="outline: 0px;"><span style="outline: 0px;color: rgb(0, 122, 170);">一、治疗肺炎支原体感染,首选药物是什么?</span></strong></span>
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<span style="outline: 0px;font-size: 16px;">大环内酯类药物是治疗肺炎支原体感染的首选药物。常用的大环内酯类药物包括阿奇霉素、红霉素、克拉霉素等。近年来,随着大环内酯类药物在儿童呼吸道感染中的广泛应用,儿童耐药肺炎支原体感染呈上升趋势。</span>
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<span style="font-size: 16px;"><span style="outline: 0px;color: rgb(0, 122, 170);"><strong style="outline: 0px;"><span style="outline: 0px;">二、一旦出现耐药,有无替代药物?</span></strong></span></span>
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<span style="outline: 0px;font-size: 16px;">肺炎支原体感染患者如果对大环内酯类药物出现耐药,那么有两类替代性药物。</span>
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<span style="outline: 0px;font-size: 16px;">一类是新型四环素类抗菌药物,主要包括多西环素和米诺环素。对耐药肺炎支原体肺炎有确切疗效。由于可能导致牙齿发黄和牙釉质发育不良,仅适用于8岁以上儿童。8岁以下儿童属于超说明书用药。米诺环素的作用相对较强,多西环素的安全性较高,在推荐剂量和疗程内,尚无持久牙齿黄染的报道。</span>
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<span style="outline: 0px;font-size: 16px;">另一类替代药物为喹诺酮类药物,常用的为左氧氟沙星、环丙沙星、莫西沙星等,由于存在骨骼肌腱方面的潜在风险,我国18岁以下儿童使用属超说明书用药。临床上,大环内酯类药物仍作为一线药物推荐使用,但存在耐药时,亦可根据病情选用四环素及喹诺酮类药物。</span>
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<span style="font-size: 16px;"><span style="outline: 0px;color: rgb(0, 122, 170);"><strong style="outline: 0px;"><span style="outline: 0px;">三、支原体肺炎如何治疗?是否需要住院?</span></strong></span></span>
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<span style="outline: 0px;font-size: 16px;">首先看支原体肺炎是轻症还是重症。轻症经过大环内酯类药物如阿奇霉素、克拉霉素、红霉素治疗,一般均能控制病情,但体温正常后,咳嗽可能还会持续2周左右,胸片肺炎阴影基本均可吸收,可不复查胸片。</span>
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<span style="outline: 0px;font-size: 16px;">重症患者需要住院,通过大环内酯类药物静脉输液治疗。因我国耐药率高,之前若用过大环内酯类药物3天无效可更换为新型四环素类药物如米诺环素等,更严重的应用左氧氟沙星等药物。重者可能有混合病毒或者细菌感染,也需要加用相应的药物联合治疗。</span>
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<span style="outline: 0px;color: rgb(0, 122, 170);font-size: 16px;"><strong style="outline: 0px;">四、国产、进口阿奇霉素效果有差别吗?</strong></span>
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<span style="outline: 0px;font-size: 16px;">目前治疗的药物基本国产化,尤其阿奇霉素,效果和国外进口基本一致。</span>
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